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1

06-Methyldeoxyguanosine in oesophageal dna among individuals at high risk of oesophageal cancer

D. Umbenhauer, C. P. Wild, R. Montesano, R. Saffhill, J. M. Boyle, N. Huh, U. Kirstein, J. Thomale, M. F. Rajewsky, S. H. Lu

Journal:

International Journal of Cancer

Année:

1985

Langue:

english

Fichier:

PDF, 513 KB

english, 1985

2

Relevance of N-nitrosamines to esophageal cancer in China

Lu Shih-Hsin, Ruggero Montesano, Zhang Ming-Shu, Feng Luo, Luo Feng-Ji, Chui Shao-Xing, Diena Umbenhauer, R. Saffhill, M. F. Rajewsky

Journal:

Journal of Cellular Physiology

Année:

1986

Langue:

english

Fichier:

PDF, 848 KB

english, 1986

3

A liquid scintillation counting method that allows recovery of compounds in high yield for further analysis

Journal:

Analytical Biochemistry

Année:

1981

Langue:

english

Fichier:

PDF, 291 KB

english, 1981

4

The synthesis of oligoribonucleotides—VIII: The preparation of ribonucleoside 2′,5′-bisketals

D.P.L. Green, T. Ravindranathan, C.B. Reese, R. Saffhill

Journal:

Année:

1970

Langue:

english

Fichier:

PDF, 941 KB

english, 1970

5

4-methoxytetrahydropyran-4-yl : A symmetrical alternative to the tetrahydropyranyl protecting group

C.B. Reese, R. Saffhill, J.E. Sulston

Journal:

Année:

1970

Langue:

english

Fichier:

PDF, 576 KB

english, 1970

6

Strand breaks arising from the repair of the 5-bromodeoxyuridine-substituted template and methyl methanesulphonate-induced lesions can explain the formation of sister chromatid exchanges

R. Saffhill, C. H. Ockey

Journal:

Année:

1985

Langue:

english

Fichier:

PDF, 892 KB

english, 1985

7

Detection by DNA polymerase I of breaks produced in rat liver chromatin in vivo by alklating agents

SAFFHILL, R., COOPER, HELEN K., ITZHAKI, RUTH F.

Journal:

Année:

1974

Fichier:

PDF, 494 KB

1974

8

Mutagenesis of Chinese hamster cells is facilitated by thymidine and deoxycytidine

SAFFHILL, ROY, ABBOTT, PETER J.

Journal:

Année:

1979

Fichier:

PDF, 123 KB

1979

9

Terminal deoxynucleotidyl transferase in a case of PH1 positive infant chronic myelogenous leukaemia

Saffhill, R, Dexter, T M, Muldal, S, Testa, N G, Jones, P M, Joseph, A

Journal:

British Journal of Cancer

Année:

1976

Langue:

english

Fichier:

PDF, 599 KB

english, 1976

10

The detection of alkylation damage in the DNA of human gastrointestinal tissues

Hall, CN, Badawi, AF, O'Connor, PJ, Saffhill, R

Journal:

British Journal of Cancer

Année:

1991

Langue:

english

Fichier:

PDF, 1.07 MB

english, 1991

11

The action of rat cytosol enzymes on some methylated nucleic acid components produced by the carcinogenic N-nitroso compounds

P.J. O'Connor, R. Saffhill

Journal:

Chemico-Biological Interactions

Année:

1979

Langue:

english

Fichier:

PDF, 1.01 MB

english, 1979

12

The formation of acetylaminofluorene adducts in poly(dC-dG) and poly(dA-dT) on reaction with N-acetoxy-2-acetylaminofluorene and the effect of such modification upon the polymers as templates for DNA polymerases

Roy Saffhill, Peter J. Abbott

Journal:

Chemico-Biological Interactions

Année:

1983

Langue:

english

Fichier:

PDF, 1017 KB

english, 1983

13

Iodo- and bromodeoxyuridine are excised at different rates from DNA of mouse tongue keratinocytes in vitro

W.J. Hume, R. Saffhill

Journal:

Chemico-Biological Interactions

Année:

1986

Langue:

english

Fichier:

PDF, 364 KB

english, 1986

14

The degradation of 5-iododeoxyuridine and 5-bromodeoxyuridine by serum from different sources and its consequences for the use of the compounds for incorporation into DNA

R. Saffhill, W.J. Hume

Journal:

Chemico-Biological Interactions

Année:

1986

Langue:

english

Fichier:

PDF, 440 KB

english, 1986

15

The incorporation of O6-methyldeoxyguanosine monophosphate and O4-methyldeoxythymidine monophosphate into polynucleotide templates leads to errors during subsequent in vitro DNA synthesis

Roy Saffhill, J.A. Hall

Journal:

Chemico-Biological Interactions

Année:

1985

Langue:

english

Fichier:

PDF, 552 KB

english, 1985

16

Radioimmunoassay (RIA) O6-methyldeoxyguanosine: validation and analysis of small cell samples

C.P. Wild, R. Saffhill, J.M. Boyle

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1984

Langue:

english

Fichier:

PDF, 75 KB

english, 1984

17

Mechanisms of carcinogenesis induced by alkylating agents

R. Saffhill, G.P. Margison, P.J. O'Connor

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Année:

1985

Langue:

english

Fichier:

PDF, 2.68 MB

english, 1985

18

In vitro miscoding of alkylthymines with DNA and RNA polymerases

Journal:

Chemico-Biological Interactions

Année:

1985

Langue:

english

Fichier:

PDF, 630 KB

english, 1985

19

Measurement of the transit time for cells through the epidermis and stratum corneum of the mouse and guinea-pig

C. S. Potten, R. Saffhill, H. I. Maibach

Journal:

Cell Proliferation

Année:

1987

Langue:

english

Fichier:

PDF, 591 KB

english, 1987

20

A Study of the Template Properties of Chromatin for DNA Polymerase I and of the Effects of Ionising Radiation

Ruth F. Itzhaki, R. Saffhill

Journal:

Année:

1973

Langue:

english

Fichier:

PDF, 671 KB

english, 1973

21

Selective phosphorylation of the cis-2', 3'-diol of unprotected ribonucleosides with trimetaphosphate in aqueous solution

Journal:

Journal of Organic Chemistry

Année:

1970

Langue:

english

Fichier:

PDF, 442 KB

english, 1970

22

The incorporation of wrong bases by DNA polymerase I following γ-irradiation of DNA-like templates

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Année:

1974

Langue:

english

Fichier:

PDF, 509 KB

english, 1974

23

Molecular size and fidelity of DNA polymerase α from the regenerating liver of the rat

J.G. Salisbury, P.J. O'Connor, R. Saffhill

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Année:

1978

Langue:

english

Fichier:

PDF, 302 KB

english, 1978

24

DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by O6-methylguanine

Peter J. Abbott, Roy Saffhill

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Année:

1979

Langue:

english

Fichier:

PDF, 702 KB

english, 1979

25

The induction of errors during in vitro DNA synthesis following chloroacetaldehyde-treatment of poly(dA-dT) and poly(dC-dG) templates

Hall, Janet A., Saffhill, Roy, Green, Trevor, Hathway, David E.

Journal:

Année:

1981

Langue:

english

Fichier:

PDF, 569 KB

english, 1981

26

The effect of ionising radiation and chemical methylation upon the activity and accuracy of E. coli DNA polymerase I

Journal:

Biochemical and Biophysical Research Communications

Année:

1974

Langue:

english

Fichier:

PDF, 309 KB

english, 1974

27

The comparative effects of short-term DNA inhibition on replicon synthesis in mammalian cells

C.H. Ockey, R. Saffhill

Journal:

Experimental Cell Research

Année:

1976

Langue:

english

Fichier:

PDF, 4.09 MB

english, 1976

28

The competitive miscoding of O6-methylguanine and O6-ethylguanine and the possible importance of cellular deoxynucleoside 5′-triphosphate pool sizes in mutagenesis and carcinogenesis

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Année:

1986

Langue:

english

Fichier:

PDF, 537 KB

english, 1986

29

The Large Scale Synthesis and Chromatographic and Spectral Properties of a Series of Alkylated Thymine and Uracil-Containing Nucleosides. O 2 -, 3- and O 4 -Alkylpyrimidine Derivatives

Journal:

Nucleosides and Nucleotides

Année:

1987

Langue:

english

Fichier:

PDF, 479 KB

english, 1987

30

In vitro selection of bacteriophage Qβ ribonucleic acid variants resistant to ethidium bromide

Saffhill, R., Schneider-Bernloehr, H., Orgel, L.E., Spiegelman, S.

Journal:

Journal of Molecular Biology

Année:

1970

Langue:

english

Fichier:

PDF, 609 KB

english, 1970

31

Symmetrical alternative to the tetrahydropyranyl protecting group

Reese, Colin B., Saffhill, R., Sulston, J. E.

Journal:

Journal of the American Chemical Society

Année:

1967

Langue:

english

Fichier:

PDF, 405 KB

english, 1967

32

Oligonucleotide synthesis via phosphotriester intermediates: the phenyl-protecting group

Reese, C. B., Saffhill, R.

Journal:

Chemical Communications (London)

Année:

1968

Langue:

english

Fichier:

PDF, 162 KB

english, 1968

33

Approaches to oligoribonucleotide synthesis via phosphotriester intermediates

van Boom, J. H., Burgers, P. M. J., Owen, G. R., Reese, C. B., Saffhill, R.

Journal:

Journal of the Chemical Society D Chemical Communications

Année:

1971

Langue:

english

Fichier:

PDF, 308 KB

english, 1971

34

Physico-Chemical Properties of Nucleic Acids. Vol. 2. Structural Studies on Nucleic Acids and Other Biopolymers

Itzhaki, Ruth F., Saffhill, R.

Journal:

International Journal of Radiation Biology

Année:

1974

Langue:

english

Fichier:

PDF, 83 KB

english, 1974

35

Accessibility of chromatin to DNA polymerase I and location of the F1 histone

Saffhill, Roy, Itzhaki, Ruth F.

Journal:

Nucleic Acids Research

Année:

1975

Langue:

english

Fichier:

PDF, 666 KB

english, 1975

36

Physico-Chemical Properties of Nucleic Acids

Itzhaki, Ruth F., Saffhill, R.

Journal:

International Journal of Radiation Biology

Année:

1974

Langue:

english

Fichier:

PDF, 91 KB

english, 1974

37

Errors in DNA synthesis induced by aflatoxin B 1 modification of poly(dC-dG)

Chu, Y.-H, Saffhill, R.

Journal:

Année:

1983

Langue:

english

Fichier:

PDF, 372 KB

english, 1983

38

Genetic Evidence for Nucleotide Excision Repair of O6-Alkylguanine in Mammalian Cells

BOYLE, J. M., DURRANT, L. G., WILD, C. P., SAFFHILL, R., MARGISON, G. P.

Journal:

Journal of Cell Science

Année:

1987

Langue:

english

Fichier:

PDF, 4.65 MB

english, 1987

39

Phenobarbital: a non-genotoxic agent which induces the repair of O 6 -methylguanine from hepatic DNA

O'Connor, P.J., Fida, S., Fan, C.Y., Bromley, M., Saffhill, R.

Journal:

Année:

1988

Langue:

english

Fichier:

PDF, 2.14 MB

english, 1988

40

The incorporation of O 4 -methylthymidine into V79A cell DNA when present in the cell culture medium

Saffhill, Roy, Fox, Margaret

Journal:

Année:

1980

Langue:

english

Fichier:

PDF, 484 KB

english, 1980

41

Radioimmunoassay of O 6 -methyldeoxyguanosine in DNA of cells alkylated in vitro and in vivo

Wild, C.P., Smart, Gail, Saffhill, R., Boyle, J.M.

Journal:

Année:

1984

Fichier:

PDF, 15 KB

1984

42

The incorporation of O 6 -methyldeoxyguanosine and O 4 -methyldeoxythymidine monophosphates into DNA by DNA polymerases I and α

Hall, Janet A., Saffhill, Roy

Journal:

Nucleic Acids Research

Année:

1983

Langue:

english

Fichier:

PDF, 384 KB

english, 1983

43

The presence of terminal deoxynucleotidyl transferase in the N-methyl-N-nitrosourea induced leukaemia in BDF1 mice and its effect on the accuracy of the DNA polymerases

Saffhill, R., Chaudhuri, L.

Journal:

Nucleic Acids Research

Année:

1976

Langue:

english

Fichier:

PDF, 370 KB

english, 1976

44

Chemical adaptation of M. luteus induces repair functions for O-alkylated DNA pyrimidines

Riazuddin, S., Athar, A., Saffhill, R.

Journal:

Nucleic Acids Research

Année:

1985

Langue:

english

Fichier:

PDF, 525 KB

english, 1985

45

In vitro reaction of N-n-butyl-N-nitrosourea and n-butyl methanesulphonate with guanine and thymine bases of DNA

Journal:

Année:

1984

Langue:

english

Fichier:

PDF, 462 KB

english, 1984

46

DNA synthesis with methylated poly(dA-dT) templates: possible role of O 4 -methylthymine as a pro-mutagenic base

Abbott, Peter J., Saffhill, Roy

Journal:

Nucleic Acids Research

Année:

1977

Langue:

english

Fichier:

PDF, 346 KB

english, 1977

47

Formation of O 2 -methylthymine in poly(dA-dT) on methylation with N-methyl-N-nitrosourea and dimethyl sulphate. Evidence that O 2 -methylthymine does not miscode during DNA synthesis

Saffhill, Roy, Abbott, Peter J.

Journal:

Nucleic Acids Research

Année:

1978

Langue:

english

Fichier:

PDF, 300 KB

english, 1978

48

Formation and Persistence of Isoniazid-DNA Adducts in Mouse Tissues

Maru, G.B., Bhide, S., Saffhill, R., O'Connor, P.J.

Journal:

Human & Experimental Toxicology

Année:

1987

Langue:

english

Fichier:

PDF, 416 KB

english, 1987

49

Repair of alkylated purines in the hepatic DNA of mitochondria and nuclei in the rat

Myers, K.A., Saffhill, R., O'Connor, P.J.

Journal:

Année:

1988

Langue:

english

Fichier:

PDF, 2.92 MB

english, 1988

50

Delayed DNA maturation, a possible cause of the elevated sister-chromatid exchange in Bloom's syndrome

Ockey, C.H., Saffhill, R.

Journal:

Année:

1986

Langue:

english

Fichier:

PDF, 517 KB

english, 1986